The Hotel Colon Buenos Aires is located on Carlos Pelligrini and is well suited for business and leisure travelers alike. The hotel is situated near the City Portena, Calle Corrientes, the Colon Theatre, and the Obelisco, and other points of interest can be easily accessed from the hotel. The Hotel Colon Buenos Aires is located near five underground lines as well as the city's bus system. Public transportation can take guests to points of interest within the city as well as to the international airport. Taxi cabs and shuttles are also available to provide airport transit.

Each of the 173 rooms in the 14 story Hotel Colon Buenos Aires offers guests climate controls, a minibar, TV, wireless Internet, a hairdryer, a safe, and toiletries. All rooms are soundproofed to ensure guest comfort.

The Hotel Colon Buenos Aires is located near many restaurants and shops as well as theaters and other amenities. Amenities onsite include an exclusive international restaurant, an outdoor heated pool, a solarium, a twenty four hour bar, laundry and valet service, and medical services.